Actually, the research WAS done
The Cialis insert states specifically that under No circumstance, none, can any nitrates be administered within 72 hours of injesting a single cialis tab. Now that's a little scary if you are a cardiac patient, and might need nitroglycerin in an unexpected emergency situation. Certainly gives me pause at the thought of prescribing it.
Poppers are no different from nitro, although it is more potent. The danger lies is a sudden drop in your blood pressure when the two drugs are combined. It isn't as if there is a toxic interaction that will kill you, but there is no way to predict just how low your pressure will drop, and how sucessful medication will be to get it back up if needed.
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